CHILDHOOD CANCER REPOSITORY

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Alex's Lemonade Stand Foundation

ALT EST Unknown

RequestCell LinePhase of Therapy Sample TypeMYCNALKTMMTp53p53pO2  
        2%5%20%
SK-N-FIPD NWTALTM246RNF  
CHLA-90PDbone marrowNF1245VALTE286KNF  
COG-N-512 PDbone marrow210 ALTWT 
COG-N-515PDbone marrow183 ALTWT 
COG-N-569hnbDxbone marrow  ALTWT   
COG-N-700Dxtumor  ALT  
LA-N-6PDbone marrowND1091NEST F  
CHLA-132PDbone marrowN EST    
COG-N-291PDbone marrow3WTEST    
COG-N-323Dxtumor2WTEST    
COG-N-325PDtumorAWTEST    
COG-N-387hPD 152WTEST    
COG-N-442hDxleft bone marrow2WTEST    
COG-N-509hnbDxbone marrow2 EST    
COG-N-518Dxbone marrow4 EST NF
COG-N-562hnbDxtumorN EST  
NB-EBc1PD NWT     
SMS-KANDxsolid tumorAWT  F  
SMS-KANRPDbone marrowAWT  F  
SMS-MSNDxbone marrow       
CHLA-8PDtumorAWT  F  
CHLA-21PDbone marrowA      
CHLA-22PDbone marrowN      
CHLA-27Dxbone marrowAF1174L     
CHLA-28PDbone marrowAF1245C     
CHLA-34PDbone marrowN      
CHLA-35Dxbone marrow       
CHLA-41PDtumorAWT     
CHLA-43Dxbone marrow WT     
CHLA-46PDtumorAWT     
CHLA-51PDbone marrowNWT  F  
CHLA-54Dx A      
CHLA-58PDtumor       
CHLA-70PDbone marrowN      
CHLA-72PDperipheral bloodA      
CHLA-78Dxbone marrow       
CHLA-81PDtumorA      
CHLA-83Dxbone marrow       
CHLA-84Dxtumor       
CHLA-89Dxtumor       
CHLA-95PDtumorAR1275Q     
CHLA-100Dxtumor       
CHLA-101Dxbone marrow       
CHLA-102PDtumorA      
CHLA-103PDtumor       
CHLA-105Dxbone marrow       
CHLA-108PDbone marrowA      
CHLA-110PDbone marrowA      
CHLA-123Dxperipheral bloodA      
CHLA-125PDbone marrowA      
CHLA-126Dxbone marrow       
CHLA-127PDtumor       
CHLA-134PDbone marrowAWT  NF  
CHLA-137Dxtumor       
CHLA-138Dxbone marrow       
CHLA-140PDbone marrowNWT     
CHLA-142Dxbone marrow       
CHLA-146PDbone marrowN      
CHLA-150PDbone marrowNR1275Q     
CHLA-151DxtumorAR1275Q     
CHLA-160Dxtumor       
CHLA-161PDbone marrow       
CHLA-183PDbone marrowN      
CHLA-188LPDbone marrowAWT     
CHLA-188RPDbone marrowAWT     
CHLA-189PDperipheral blood       
CHLA-232PD A      
CHLA-253PDtumorAWT     
COG-N-272Dxsolid tumor       
COG-N-284PDliver metastasis       
COG-N-296Dxbone marrowA      
COG-N-302Dxsolid tumor       
COG-N-475hPDtumor119R1275Q    
COG-N-496Dxbone marrow74WT   
COG-N-503hDxbone marrowN      
COG-N-504Dxbone marrowN     
COG-N-507hPDbone marrow97      
COG-N-508hPDbone marrowA      
COG-N-513PDbone marrowA    
COG-N-514PDbone marrowA     
COG-N-521Dxbone marrow     
COG-N-522hDxbone marrow       
COG-N-523hDxbone marrow       
COG-N-524hDxbone marrow       
COG-N-527hDxbone marrow      
COG-N-531hDxbone marrowA      
COG-N-532Dxbone marrowN    
COG-N-539DxtumorA    
COG-N-542hDxbone marrowA      
COG-N-543hDxbone marrowA     
COG-N-544Dxbone marrow     
COG-N-546hDxbone marrowA     
COG-N-548Dxbone marrowN    
COG-N-549PDtumorNF1174L   
COG-N-550hDxbone marrowA     
COG-N-552hDXbone marrowA     
COG-N-554Dxbone marrowA    
COG-N-555hDxbone marrow       
COG-N-556Dxbone marrowA    
COG-N-558hDxtumorA     
COG-N-563Dxbone marrowA    
COG-N-565PDright bone marrowN    
COG-N-566DxbloodN    
COG-N-570hDxbloodA     
COG-N-571Dxbone marrowN     
COG-N-572hDxbone marrowN      
COG-N-574Dxbone marrowA    
COG-N-575Dxbone marrowA    
COG-N-576h2PDbone marrow       
COG-N-577PD-PMblood     
COG-N-578PDbone marrowN    
COG-N-579hPDbone marrowN     
COG-N-581hDxbone marrowA     
COG-N-582hDxbone marrowA     
COG-N-585Dxbone marrowA    
COG-N-586Dxbone marrowA    
COG-N-587hDxbone marrowN    
COG-N-591Dxbone marrowA    
COG-N-592Dxbone marrowA    
COG-N-596hPDtumorA     
COG-N-597hDxbone marrowN     
COG-N-598h2Dxbone marrowN     
COG-N-599PDbone marrowA    
COG-N-600Dxbone marrowA    
COG-N-601h2Dxbone marrowA     
COG-N-602Dxbone marrow     
COG-N-614Dxbone marrow     
COG-N-616hDxbone marrowN      
COG-N-617hDxbone marrow      
COG-N-618PDbone marrowNWT   
COG-N-619PDbone marrowNWT   
COG-N-621hPDbone marrow      
COG-N-623PDtumorAWT   
COG-N-626hDxbone marrow       
COG-N-627hDxtumorA    
COG-N-628Dxbone marrowAWT   
COG-N-629Dxbone marrow     
COG-N-632hPDbone marrow       
COG-N-633PDbone marrow     
COG-N-635hDxbone marrow      
COG-N-636DxtumorAWT   
COG-N-637Dxbone marrow     
COG-N-638hDxbone marrow      
COG-N-639hDxbone marrow      
COG-N-640hDxbone marrow      
COG-N-645PD-PMblood       
COG-N-646Dxbone marrow     
COG-N-647Dxbone marrow     
COG-N-652h2Dxbone marrowN       
COG-N-654hDxbone marrow       
COG-N-660hnbPD-PMbloodN      
COG-N-662hDxbone marrow       
COG-N-663h2Dxbone marrow       
COG-N-667hDxbone marrow       
COG-N-671hDxbone marrow       
COG-N-672PD-PMblood     
COG-N-675 Dxbone marrow     
COG-N-677hnbPDbone marrow       
COG-N-678hPDbone marrow       
COG-N-679Dxbone marrow     
COG-N-680PDbone marrow      
COG-N-683Dxbone marrow     
COG-N-685PD-PMblood     
COG-N-696hDxbone marrow       
COG-N-697hDxtumor      
COG-N-698Dxtumor      
COG-N-701Dxbone marrow      

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive