CHILDHOOD CANCER REPOSITORY

Powered by

Alex's Lemonade Stand Foundation

Neuroblastoma

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

Please click at the top logo to return to home page.

   
RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53Available Oxygen Conditions
        2%5%20%
FelixPD-PMbloodNF1245VTERT+R342*F ✓✓
FU-NB-2006PD-PMbloodNWTTERT+   ✓✓
LA-N-5Dxbone marrowAR1275QTERT+    ✓
LA-N-6PDbone marrowND1091NEST F  ✓
NB-1643Dx AR1275QTERT+    ✓
NB-Ebc1PD NWT     ✓
SK-N-BE(1)Dx AWTTERT+WTF  ✓
SK-N-BE(2)PD AWTTERT+C135FNF  ✓
SK-N-FIPD NWTALTM246RNF  ✓
SMS-KANDxsolid tumorAWT  F  ✓
SMS-KANRPDbone marrowAWT  F  ✓
SMS-KCNDxsolid tumorAR1275QTERT+ F  ✓
SMS-KCNRPDbone marrowAF1174LTERT+ F  ✓
SMS-LHNPDsolid tumorN TERT+ F  ✓
SMS-MSNDxbone marrow       ✓
SMS-SANDxbone marrowAF1174LTERT+ F  ✓
CHLA-8PD-BMTtumorAWT F  ✓
CHLA-11PD-BMT, PMperipheral bloodAWTTERT+ NF  ✓
CHLA-12PD-BMT, PMbone marrowAWTTERT+ NF  ✓
CHLA-14Dx A TERT+    ✓
CHLA-15DxtumorNR1275QTERT+ F  ✓
CHLA-16Dxpleural fluidNR1275QTERT+    ✓
CHLA-20PDtumor (neck)NR1275QTERT+ F  ✓
CHLA-21PDbone marrowA      ✓
CHLA-22PDbone marrowN      ✓
CHLA-24PDpleural fluidAWTTERT+    ✓
CHLA-27Dxbone marrowAF1174L     ✓
CHLA-28PDbone marrowAF1245C     ✓
CHLA-29Dxbone marrowAWTTERT+    ✓
CHLA-30DxtumorA TERT+    ✓
CHLA-34PDbone marrowN      ✓
CHLA-35Dxbone marrow       ✓
CHLA-41PDtumorAWT     ✓
CHLA-42Dxbone marrowNR1275QTERT+ F  ✓
CHLA-43Dxbone marrow WT     ✓
CHLA-44Dxbone marrow  TERT+    ✓
CHLA-46PDtumorAWT     ✓
CHLA-51PD-BMTbone marrowNWT F  ✓
CHLA-52PD-PMbone marrowAF1174LTERT+ NF  ✓
CHLA-53PD-PMperipheral bloodAF1174LTERT+ NF  ✓
CHLA-58PDtumor       ✓
CHLA-60PD-PMbone marrowNWTTERT+ F  ✓
CHLA-61PD-PMperipheral bloodNR1275QTERT+ F  ✓
CHLA-70PDbone marrowN      ✓
CHLA-72PDperipheral bloodA      ✓
CHLA-78Dxbone marrow       ✓
CHLA-79PD-BMTtumorNWTTERT+ F  ✓
CHLA-81PDtumorA      ✓
CHLA-83Dxbone marrow       ✓
CHLA-84Dxtumor       ✓
CHLA-89Dxtumor       ✓
CHLA-90PD-BMTbone marrowNF1245VALTE286KNF  ✓
CHLA-95PDtumorAR1275Q     ✓
CHLA-100Dxtumor       ✓
CHLA-101Dxbone marrow       ✓
CHLA-102PDtumorA      ✓
CHLA-103PDtumor       ✓
CHLA-105Dxbone marrow       ✓
CHLA-108PDbone marrowA      ✓
CHLA-110PDbone marrowA      ✓
CHLA-119PDbone marrowAWTTERT+ NF  ✓
CHLA-122Dxbone marrowAWTTERT+ F  ✓
CHLA-123Dxperipheral bloodA      ✓
CHLA-125PDbone marrowA      ✓
CHLA-126Dxbone marrow       ✓
CHLA-127PDtumor       ✓
CHLA-132PDbone marrowN EST    ✓
CHLA-134PD-BMTbone marrowAWT  NF  ✓
CHLA-136PD-BMTperipheral bloodAWTTERT+WTF  ✓
CHLA-137Dxtumor       ✓
CHLA-138Dxbone marrow       ✓
CHLA-140PDbone marrowNWTTERT+    ✓
CHLA-142Dxbone marrow       ✓
CHLA-144Dxbone marrowAWTTERT+    ✓
CHLA-145PDbone marrowAAWTTERT+   ✓
CHLA-146PDbone marrowN      ✓
CHLA-150PDbone marrowNR1275Q     ✓
CHLA-151DxtumorAR1275Q     ✓
CHLA-160Dxtumor       ✓
CHLA-161PDbone marrow       ✓
CHLA-171PD-PMperiperhal bloodNWTTERT+WTNF  ✓
CHLA-172PD-BMTbone marrowNWTTERT+V216LNF  ✓
CHLA-183PDbone marrowN      ✓
CHLA-188LPD-BMTbone marrowAWT     ✓
CHLA-188RPD-BMTbone marrowAWT     ✓
CHLA-225PD-PMpleural fluidAWTTERT+ NF  ✓
CHLA-232PD A      ✓
CHLA-247PDbone marrowAWTTERT+    ✓
CHLA-253PDtumorAWT     ✓
COG-N-261Dxtumor34WTTERT+    ✓
COG-N-263Dxtumor48NWTTERT+   ✓
COG-N-265 Dxtumor123WTTERT+    ✓
COG-N-269PDlymph node2WTTERT+    ✓
COG-N-272Dxsolid tumor       ✓
COG-N-276Dxbone marrowAWTTERT+    ✓
COG-N-278Dxsolid tumor26      ✓
COG-N-283Dxsolid tumor88 TERT+    ✓
COG-N-284PDliver metastasis       ✓
COG-N-289PDsolid tumor160WTTERT+    ✓
COG-N-290Dxsolid tumor   TERT+   ✓
COG-N-291PDbone marrow3NWTEST   ✓
COG-N-293Dxsolid tumor56AWTTERT+   ✓
COG-N-294Dxsolid tumor42R1275QTERT+ NF  ✓
COG-N-295Dxsolid tumor2 F1174LTERT+    ✓
COG-N-296Dxbone marrowA      ✓
COG-N-297Dxsolid tumor24WTTERT+    ✓
COG-N-298Dxsolid tumor11R1275QTERT+    ✓
COG-N-299Dxsolid tumor193WTTERT+    ✓
COG-N-302Dxsolid tumor       ✓
COG-N-303Dxsolid tumor52WTTERT+    ✓
COG-N-305Dxsolid tumor133WTTERT+    ✓
COG-N-312Dxbone marrow62 TERT+    ✓
COG-N-316Dxbone marrow2TERT+     ✓
COG-N-318PDsolid tumor400WTTERT+    ✓
COG-N-321PDbone marrow29 TERT+ NF  ✓
COG-N-322Dxsolid tumor323WTTERT+    ✓
COG-N-323Dxtumor2WTEST    ✓
COG-N-324Dxbone marrow61WTTERT+    ✓
COG-N-325PDtumorAWTEST    ✓
COG-N-327PDbone marrow300WTTERT+   ✓✓
COG-N-328hDxtumor130WTTERT+   ✓ 
COG-N-331Dxbone marrow85WTTERT+    ✓
COG-N-333Dxbone marrow144F1174LTERT+    ✓
COG-N-334PDbone marrow30WTTERT+   ✓✓
COG-N-346PDtumor2WTTERT+   ✓ 
COG-N-347Dxbone marrow248WTTERT+    ✓
COG-N-349Dxbone marrow90WTTERT+   ✓✓
COG-N-353Dxbone marrow38WTTERT+   ✓✓
COG-N-354Dxbone marrow66 TERT+   ✓✓
COG-N-367Dxbone marrow22R1275QTERT+   ✓✓
COG-N-372hPDbone marrowNWTTERT+   ✓ 
COG-N-373Dxbone marrow78WTTERT+    ✓
COG-N-387hPD 152WTEST   ✓ 
COG-N-399PD-PMblood50WTTERT+ F ✓✓
COG-N-415PD-PMblood400F1174LTERT+   ✓✓
COG-N-421PD-PMblood34WTTERT+ NF   
COG-N-440PD-PMblood250WTTERT+ F ✓ 
COG-N-442hDxleft bone marrow2WTEST   ✓ 
COG-N-443hPDright bone marrow1F1245CTERT+  ✓✓✓
COG-N-445Dxbone marrow117WTTERT+  ✓✓✓
COG-N-452PD-PMblood62F1174LTERT+ F✓✓✓
COG-N-453PD-PMtumor318WTTERT+ F✓✓ 
COG-N-462hDxright bone marrowAWTTERT+  ✓  
COG-N-463h2Dxleft bone marrow277WTTERT+  ✓✓ 
COG-N-469hPDleft bone marrow2F1174LTERT+  ✓✓✓
COG-N-470PD-PMblood2F1174LTERT+ F✓✓ 
COG-N-471PD-PMblood360WTTERT+ NF ✓* 
COG-N-473hPDbone marrow150WTTERT+  ✓✓✓
COG-N-474Dxbone marrow338F1174LTERT+   ✓ 
COG-N-475hPDtumor119R1275Q    ✓✓
COG-N-476PD-BMTtumor3WTTERT+   ✓✓
COG-N-478PDleft bone marrow3WTTERT+   ✓ 
COG-N-480h2Dxright bone marrow42WTTERT+  ✓  
COG-N-482hPDbone marrowA TERT+  ✓✓ 
COG-N-485hDxbone marrow36 TERT+  ✓✓ 
COG-N-490hDxbone marrow208WTTERT+  ✓✓ 
COG-N-491hDxperipheral blood370WTTERT+   ✓ 
COG-N-496Dxbone marrow74WT   ✓✓✓
COG-N-497Dxbone marrow40 TERT+  ✓✓✓
COG-N-500Dxbone marrowN TERT+   ✓✓
COG-N-503hDxbone marrowN     ✓ 
COG-N-504Dxbone marrow2     ✓✓
COG-N-505PD-PMblood96WTTERT+ F✓✓✓
COG-N-507hPDbone marrow97     ✓ 
COG-N-508hPDbone marrow44     ✓ 
COG-N-509hnbDxbone marrow2 EST   ✓* 
COG-N-511h2PDbone marrow2 TERT+  ✓✓ 
COG-N-512 PDbone marrow210 ALTWT ✓✓✓
COG-N-513PDbone marrow132    ✓✓✓
COG-N-514PDbone marrow324    ✓✓ 
COG-N-515PDbone marrow183 ALTWT ✓✓✓
COG-N-518Dxbone marrow4 EST NF✓✓✓
COG-N-519PD-PMblood106WTTERT+ NF✓✓✓
COG-N-521Dxbone marrow     ✓✓✓
COG-N-522hDxbone marrow252     ✓ 
COG-N-523hDxbone marrow      ✓ 
COG-N-524hDxbone marrow      ✓ 
COG-N-527hDxbone marrow     ✓✓ 
COG-N-529PD-PMblood2WTTERT+ F✓✓✓
COG-N-531hDxbone marrowA      ✓ 
COG-N-532Dxbone marrow2    ✓✓✓
COG-N-534PD-PMblood4F1245CTERT+ NF✓✓✓
COG-N-536hPD-PMblood165R1275QTERT+ NF✓✓ 
COG-N-539Dxtumor87    ✓✓✓
COG-N-540Dxbone marrow8    ✓✓✓
COG-N-542hDxbone marrow134     ✓ 
COG-N-543hDxbone marrow392    ✓✓ 
COG-N-544Dxbone marrow8   ✓✓✓
COG-N-546hDxbone marrowA    ✓✓ 
COG-N-548Dxbone marrow2    ✓✓✓
COG-N-549PDtumor2F1174L   ✓✓✓
COG-N-550hDxbone marrow165    ✓✓ 
COG-N-552hDXbone marrow172    ✓✓ 
COG-N-553PDbone marrow175    ✓✓✓
COG-N-554Dxbone marrow59    ✓✓✓
COG-N-555hDxbone marrow250     ✓ 
COG-N-556Dxbone marrowA    ✓✓✓
COG-N-557Dxbone marrowAF1245LTERT+  ✓✓✓
COG-N-558hDxtumorA    ✓✓ 
COG-N-561PD-PMbloodA F1245ITERT+ F✓✓✓
COG-N-562 DxtumorN TERT+  ✓✓✓
COG-N-563Dxbone marrowA    ✓✓✓
COG-N-564hPD-PMbloodA TERT+  ✓✓ 
COG-N-565PDright bone marrowN    ✓✓✓
COG-N-566DxbloodN    ✓✓✓
COG-N-569hnbDxbone marrow  ALTWT  ✓ 
COG-N-570hDxbloodA    ✓✓ 
COG-N-571Dxbone marrowN     ✓✓
COG-N-572hDxbone marrowN     ✓ 
COG-N-573Dxbone marrowAWTTERT+  ✓✓✓
COG-N-574Dxbone marrowA    ✓✓✓
COG-N-575Dxbone marrowA    ✓✓✓
COG-N-576h2PDbone marrow     ✓  
COG-N-577PD-PMblood     ✓✓✓
COG-N-578PDbone marrowN    ✓✓✓
COG-N-579hPDbone marrowN    ✓✓ 
COG-N-581hDxbone marrowA    ✓✓ 
COG-N-582hDxbone marrowA    ✓✓ 
COG-N-585Dxbone marrowA    ✓✓✓
COG-N-586Dxbone marrowA    ✓✓✓
COG-N-587hDxbone marrowN    ✓✓✓
COG-N-590DxtumorAWTTERT+   ✓✓
COG-N-591Dxbone marrowA    ✓✓✓
COG-N-592Dxbone marrowA    ✓✓✓
COG-N-596hPDtumorA    ✓✓ 
COG-N-597hDxbone marrowN    ✓✓ 
COG-N-598h2Dxbone marrowN    ✓✓ 
COG-N-599PDbone marrowA    ✓✓✓
COG-N-600Dxbone marrowA    ✓✓✓
COG-N-601h2Dxbone marrowA    ✓✓ 
COG-N-602Dxbone marrow     ✓✓✓
COG-N-603DxtumorAWTTERT+  ✓✓✓
COG-N-614Dxbone marrow     ✓✓✓
COG-N-615PD-PMbloodN TERT+  ✓✓✓
COG-N-616hDxbone marrowN     ✓ 
COG-N-617hDxbone marrow     ✓✓ 
COG-N-618PD-Post XRTbone marrowNWT   ✓✓✓
COG-N-619PD-Post XRTbone marrowNWT   ✓✓✓
COG-N-621hPDbone marrow     ✓✓ 
COG-N-623PDtumorAWT   ✓✓✓
COG-N-626hDxbone marrow      ✓ 
COG-N-627hDxtumorA    ✓✓✓
COG-N-628Dxbone marrowAWT   ✓✓✓
COG-N-632hPDbone marrow      ✓ 
COG-N-633PDbone marrow     ✓✓✓
COG-N-635hDxbone marrow     ✓✓ 
COG-N-636DxtumorAWT   ✓✓✓
COG-N-637Dxbone marrow     ✓✓✓
COG-N-638hDxbone marrow     ✓✓ 
COG-N-639hDxbone marrow     ✓✓ 
COG-N-640hDxbone marrow     ✓✓ 
COG-N-645PD-PMblood       ✓
COG-N-646Dxbone marrow     ✓✓✓
COG-N-647Dxbone marrow     ✓✓✓
COG-N-651h2Dxbone marrowN    ✓ 
COG-N-652h2Dxbone marrowN       
COG-N-654hDxbone marrow      ✓ 
COG-N-660hnbPD-PMbloodN     ✓* 
COG-N-662hDxbone marrow      ✓ 
COG-N-663h2Dxbone marrow     ✓  
COG-N-667hDxbone marrow      ✓ 
COG-N-671h        ✓ 
COG-N-672PD-PMblood     ✓✓✓
COG-N-675Dxbone marrow     ✓✓✓
COG-N-677hnbPDbone marrow      ✓* 
COG-N-678hPDbone marrow      ✓ 
COG-N-679Dxbone marrow     ✓✓✓
COG-N-680PDbone marrow     ✓ ✓
COG-N-682Dxbone marrow  TERT+  ✓✓✓
COG-N-683Dxbone marrow     ✓✓✓
COG-N-685PD-PMblood     ✓✓✓
COG-N-696hDxbone marrow      ✓ 
COG-N-697hDxtumor     ✓✓ 
COG-N-698Dxtumor      ✓✓
COG-N-700Dxtumor  ALT  ✓✓✓
COG-N-701Dxbone marrow      ✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERTTERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive