CHILDHOOD CANCER REPOSITORY

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Other Cancers


PDXs, ending in an “x”, are patient direct and have never been in vitro. Xenografts ending in “m” are established from a cell line.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestPDXPhase of DiseaseSample Type ReceivedDiagnosisCell line pO2   
     2% O25% O220%O2
COG-LL-317xPDbone marrowT-cell Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-319xDxperipheral bloodPre-B Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-329xDxbone marrowT-cell Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-E-670xDxtumorEwing's Sarcoma---
COG-H-630xDxtumor (liver)Hepatoblastoma---
COG-LL-330x bone marrowAcute Lymphoblastic Leukemia (ALL)---
COG-LL-332xPDbone marrowT-cell Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-339x bone marrrowAcute Lymphoblastic Leukemia (ALL) - - -
COG-LL-343x  Pre-B Acute Lymphoblastic Leukemia (ALL) - - -
COG-LL-350xDxperipheral bloodPre-B Acute Lymphoblastic Leukemia (ALL) - - -
COG-LL-351x bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
COG-LL-355xDxbone marrowPre-B Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-375x bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
COG-LL-377x bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
COG-LL-380x  Acute Lymphoblastic Leukemia (ALL) - - -
COG-LL-394xPDbone marrowAcute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-402xDxbone marrowPre-B Acute Lymphoblastic Leukemia (ALL) - ✓ -
COG-LL-413x bone marrowPre-B Acute Lymphoblastic Leukemia (ALL) - - -
COG-LL-436xDxbone marrowAcute Lymphoblastic Leukemia (ALL) - - -
COG-LL-456xDxbone marrow  - - -
COG-LL-489xDxperipheral blood (1st draw)T-cell Leukemia - - -
COG-LL-492xDxbone marrowT-cell Leukemia - - -
COG-LL-494xDxperipheral blood (2nd draw)T-cell Leukemia - - -
COG-LL-525xDxbone marrow (right draw)Leukemia - ✓ -
COG-LL-528xDxbone marrowLeukemia - ✓ -
COG-LY-457xPD-PMbone marrow (autopsy)Burkitt's Lymphoma✓✓✓
COG-LY-458xPD-PMblood (central vein) (autopsy)Burkitt's Lymphoma✓✓✓
COG-LY-465xPD-PMblood (left subclavian) (autopsy)Burkitt's Lymphoma✓✓✓
COG-LY-465xPD-PMtumor/tumorBurkitt's Lymphoma✓✓✓
COG-R-438xPDtumorRhabdomyosarcoma---
COG-R-668xDxtumorRhabdomyosarcoma---
COG-RB-673xPD-PMpost mortem bloodRetinoblastoma-✓-
COG-N-410x tumorWilms' Tumor---
COG-W-477xPD-PMtumor (autopsy)Wilms' tumor---
COG-W-661xDxtumorWilms' Tumor---

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive