CHILDHOOD CANCER REPOSITORY

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Pediatric Sarcomas

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePDXPhase of TherapyDiagnosisSample TypeAvailable Oxygen Conditions 
      2% O25% O220% O2 
COG-OS-551h--Osteosarcomapleural fluid-✓-199
Rh18-DxRhabdomyosarcomaperineum--✓ 
Rh30-DxRhabdomyosarcomabone marrow--✓ 
Rh41-PDRhabdomyosarcomalung tumor--✓ 
CB-NJR--Rhabdomyosarcomaunknown--✓83
CHLA-33--Rhabdomyosarcomatumor--✓66
CHLA-37-DxRhabdomyosarcomatumor--✓22
COG-R-262-PD-BMTRhabdomyosarcomapericardial fluid--✓34
 COG-R-438xPDRhabdomyosarcomatumor---66
 COG-R-668xDxRhabdomyosarcomatumor---72
SMS-CTR--Rhabdomyosarcoma, embryonal--✓180
 COG-OS-712x-Osteosarcomatumor---23
 COG-OS-849x-Osteosarcomatumor---4
CHLA-50--Rhabdomyosarcomatumor--✓7
CHLA-186-PD-BMTRhabdomyosarcomaperitoneal fluid--✓11
TX-R-332 PDRhabdomyosarcomabone marrow23116 
COG-R-466h-PD-PMRhabdomyosarcoma, embryonaltumor (autopsy)-✓-8
COG-R-594h2nbCOG-R-594xDxRhabdomyosarcoma, spindle celltumor152910PDX=11
COG-R-264-PD-BMTRhabdomyosarcoma--✓3
COG-R-267--Rhabdomyosarcomabrain tumor--✓1
 COG-F-830x-Sclerosing epitheliod fibrosarcomatumor---2

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

3 - TP53 gene function
F: Functional
N: Non-Functional

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive