CHILDHOOD CANCER REPOSITORY

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Lymphoid Malignancies and Leukemia

RequestCell Line NamePDXPhase of DiseaseAge (years)Sample Type ReceivedDiagnosisAvailable Oxygen ConditionsGermline   
       2% O25% O220% O2    
-COG-LL-330x  bone marrowAcute Lymphoblastic Leukemia (ALL)---Yes39  
-COG-LL-351x  bone marrowAcute Lymphoblastic Leukemia (ALL)---Yes121  
-COG-LL-377x  bone marrowAcute Lymphoblastic Leukemia (ALL)---No87  
-COG-LL-380x   Acute Lymphoblastic Leukemia (ALL)---No99  
-COG-LL-436xDx bone marrowAcute Lymphoblastic Leukemia (ALL)---Yes308  
CHLA-221    Acute Nonlymphocytic Leukemia (ANLL)-- 160  
COG-LL-319COG-LL-319xDx peripheral bloodPre-B Acute Lymphoblastic Leukemia (ALL)-Notoo many441227
 COG-LL-343x 16 Pre-B Acute Lymphoblastic Leukemia (ALL)---No54  
 COG-LL-350xDx4peripheral bloodPre-B Acute Lymphoblastic Leukemia (ALL)---No150  
COG-LL-355COG-LL-355xDx7bone marrowPre-B Acute Lymphoblastic Leukemia (ALL)-NoPDX=2136100
COG-LL-402hCOG-LL-402xDx9bone marrowPre-B Acute Lymphoblastic Leukemia (ALL) ---Yes148  
COG-LL-403hCOG-LL-403xDx9peripheral bloodPre-B Acute Lymphoblastic Leukemia (ALL)-YesPDX=110944
SMS-SB   tumorPre-B Acute Lymphoblastic Leukemia (ALL)-- 180  
COG-LL-317COG-LL-317xPD bone marrowT-cell Acute Lymphoblastic Leukemia (ALL)-Notoo many1100428
COG-LL-329COG-LL-329xDx bone marrowT-cell Acute Lymphoblastic Leukemia (ALL)-No 13841
COG-LL-332COG-LL-332xPD bone marrowT-cell Acute Lymphoblastic Leukemia (ALL)-NoPDX=304391229
COG-LL-384h PD  T-cell Acute Lymphoblastic Leukemia (ALL)--No4949-
 COG-LL-489xDx peripheral blood (1st draw)T-cell Leukemia---Yes51  
 COG-LL-492xDx bone marrowT-cell Leukemia---Yes54  
 COG-LL-494xDx peripheral blood (2nd draw)T-cell Leukemia---Yes34  
 COG-LL-456xDx bone marrowLeukemia---Yes108  
COG-LL-528hCOG-LL-528xDx bone marrow (right draw)Leukemia-Yes21466
COG-LY-457COG-LY-457xPD-PM10bone marrow (autopsy)Burkitt's LymphomaYes48107157
COG-LY-458COG-LY-458xPD-PM10blood (central vein) (autopsy)Burkitt's LymphomaYes   
COG-LY-459 PD-PM10blood (left subclavian) (autopsy)Burkitt's LymphomaYes   
COG-LY-460COG-LY-465xPD-PM10tumor/tumorBurkitt's Lymphoma-Yes   
COG-LY-357-Dx bone marrowPre-T Lymphoblastic Lymphoma (LBL)-Yes50  
TX-LL-057hTX-LL-057xDx10bone marrowPre-B Acute Lymphoblastic Leukemia (ALL)-100-NoPDX=123  
TX-LL-179TX-LL-179xPD26peripheral bloodB-cell Acute Lymphoblastic Leukemia (ALL)2860-YesPDX=80  
 TX-LL-231xDx5bloodB-cell Acute Lymphoblastic Leukemia (ALL)---Yes95  
TX-LY-172TX-LY-183xPD7bone marrow/pleural fluidT-cell Non-Hodgkin's Lymphoma-12568YesPDX=142  
TX-LY-172TX-LY-196xPD7pleural fluidT-cell Non-Hodgkin's Lymphoma-12568YesPDX=57  
CHLA-233-   Acute Nonlymphocytic Leukemia (ANLL)-- 4  
 COG-LL-339x  bone marrrowAcute Lymphoblastic Leukemia (ALL)---No8  
 COG-LL-375x 12bone marrrowAcute Lymphoblastic Leukemia (ALL)--- No12  
COG-LL-394COG-LL-394xPD bone marrrowAcute Lymphoblastic Leukemia (ALL)-292NoPDX=5  
 COG-LL-525xDx bone marrrowLeukemia---YesPDX=7  
COG-LL-434hCOG-LL-434xDx bone marrrowT-cell Acute Lymphoblastic Leukemia (ALL) 17 NoPDX=45  
 COG-ML-428x  bone marrrowAcute Myelomonocytic Leukemia (AMMoL)--- 12  
 COG-LL-413x  bone marrrowPre-B Acute Lymphoblastic Leukemia (ALL)---Yes1   

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive