CHILDHOOD CANCER REPOSITORY

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Ewing's Family of Tumors

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell Line NamePDXPhase of DiseaseAge (years)Sample Type ReceivedDiagnosisEWS/FLI1 Statusp53Available Oxygen ConditionsVials  
         2% O25% O220%O2   
CHLA-98--tumorEwing's Sarcoma--✓107
CHLA-99--tumorEwing's Sarcoma--✓143
CHLA-237--Ewing's Sarcoma--✓143
COG-E-352-PD-PM17bloodEwing's SarcomaERG-✓✓CDX=7329128
-COG-E-670xDxtumorEwing's Sarcoma---PDX=49
TC-71-PD22Ewing's SarcomaFLI1--✓
TC-106-Dx19Ewing's Sarcoma--✓
TC-138-FLI1--✓
TC-205-FEV--✓
TC-32-Dx17Primitive Neuroectodermal Tumor (PNET)FLI1--✓
CB-AGPN-Primitive Neuroectodermal Tumor (PNET)--✓228
CB-JFEN-tumor (chest wall met)Primitive Neuroectodermal Tumor (PNET)--✓72
CHLA-9-Dx14tumor (thoracic mass)Primitive Neuroectodermal Tumor (PNET)FLI1F--✓402
CHLA-10-PD14tumor (thoracic lymph node)Primitive Neuroectodermal Tumor (PNET)FLI1N--✓351
CHLA-32-8.5tumorPrimitive Neuroectodermal Tumor (PNET)FLI1F--✓246
CHLA-56-Dxbone marrowPrimitive Neuroectodermal Tumor (PNET)--✓114
CHLA-57-Primitive Neuroectodermal Tumor (PNET)--✓121
CHLA-218-PDtumorPrimitive Neuroectodermal Tumor (PNET)--✓109
CHLA-258-PD-BMT14tumor (lung met)Primitive Neuroectodermal Tumor (PNET)FLI1--✓255
CHLA-25-PD2.6tumorPrimitive Neuroectodermal Tumor (PNET)ERGN✓358
-TX-E-270xtumor (pulmonary nodule)Ewing's Sarcoma---65
TX-E-351TX-E-351xPDtumor (left lung)Ewing's Sarcoma194856PDX=75
CHLA-113-PDPNET / medulloblastoma--✓5
CB-DGN-Primitive Neuroectodermal Tumor (PNET)--✓20
TTC-633
TTC-621
TTC-547
TTC-516
TTC-487
TTC-475
TTC-466
TTC-443
TTC-442
TTC-253
TTC-1483
TTC-1318
TC-300
TC-252
TC-249
TC-248
TC-244
TC-240
TC-215
TC-177
TC-167
TC-138
TC-135
TC-131

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive