CHILDHOOD CANCER REPOSITORY

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Alex's Lemonade Stand Foundation

Ewing's Family of Tumors

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2.
Cells established and grown in serum-free neurobasal media will end with “nb”.

The definitions for the abbreviations are given below the table. Please scroll all the way down.

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How to Request a Cell Line:

Before you begin, please open the shipping cart in a browser tab and leave that tab open until you are ready to submit your request.

Open the cell line table list pages in a second tab and make all your selections in the second tab while leaving the cart open in the first tab.

You can check your selections and make deletions from the cart in the first tab at any time.

Just click on reload or refresh in the first tab to see any changes to the cart.

When you are ready, enter your shipping information on the cart page in the first tab and submit your completed request.

(1) Select the cell line(s)/PDXs by clicking each check box next to the cell line name.
(2) Fill out the institutional or commercial/industry information at the bottom of the page.
(3) Attach a fully signed MTA (including Attachment A)
(4) Attach any additional documents required for your request (i.e. a justification for any request over 10 cell lines total)
(5) Click Submit.

For all other questions regarding your request and/or MTA, please visit our FAQ page.

To view a complete cell line description (origin, growth conditions, pictures, etc.), click on the cell line name to open a pdf data sheet to view and/or download.


RequestCell Line NamePDXPhase of DiseaseAge (years)Sample Type ReceivedDiagnosisEWS/FLI1 Statusp53Available Oxygen Conditions
         2% O25% O220%O2
CHLA-98--tumorEwing's Sarcoma--✓
CHLA-99--tumorEwing's Sarcoma--✓
CHLA-237--Ewing's Sarcoma--✓
COG-E-352-PD-PM17bloodEwing's SarcomaERG-✓✓
-COG-E-670xDxtumorEwing's Sarcoma---
TC-71-PD22Ewing's SarcomaFLI1--✓
TC-106-Dx19Ewing's Sarcoma--✓
TC-138-FLI1--✓
TC-205-FEV--✓
TC-32-Dx17Primitive Neuroectodermal Tumor (PNET)FLI1--✓
CB-AGPN-Primitive Neuroectodermal Tumor (PNET)--✓
CB-JFEN-tumor (chest wall met)Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-9-Dx14tumor (thoracic mass)Primitive Neuroectodermal Tumor (PNET)FLI1F--✓
CHLA-10-PD14tumor (thoracic lymph node)Primitive Neuroectodermal Tumor (PNET)FLI1N--✓
CHLA-32-8.5tumorPrimitive Neuroectodermal Tumor (PNET)FLI1F--✓
CHLA-56-Dxbone marrowPrimitive Neuroectodermal Tumor (PNET)--✓
CHLA-57-Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-218-PDtumorPrimitive Neuroectodermal Tumor (PNET)--✓
CHLA-258-PD-BMT14tumor (lung met)Primitive Neuroectodermal Tumor (PNET)FLI1--✓
CHLA-25-PD2.6tumorPrimitive Neuroectodermal Tumor (PNET)ERGN✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive