CHILDHOOD CANCER REPOSITORY

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Brain

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell Line NamePDXPhase of TherapyAge (years)Sample Type ReceivedDiagnosisAvailable Oxygen ConditionsVials   
       2% O25% O220%O2    
CHLA-198-Dx tumorAnaplastic Astrocytoma--✓57
CHLA-259-Dx14posterior fossaAnaplastic Medulloblastoma--✓79
BT-12-Dx0.2tumorAtypical Teratoid Rhabdoid Tumor--✓100
CHLA-135-Dx tumorAtypical Teratoid Rhabdoid Tumor--✓59
CHLA-266-Dx1.5tumorAtypical Teratoid Rhabdoid Tumor--✓225
COG-AR-359-Dx tumorAtypical Teratoid Rhabdoid Tumor-✓✓nb=13CDX=2271232
COG-AR-397hnb-PD cerebrospinal fluidAtypical Teratoid Rhabdoid Tumor-✓-42
CHLA-148-Dx bone marrowDysembryoplastic Neuroepithelial Tumor--✓94
SJ-GBM2-PD tumorGlioblastoma Multiforme--✓100
CHLA-200-PD-PM12tumorGlioblastoma Multiforme--✓151
COG-EP-383-- tumorEpendymoma-✓*✓hnb=36
COG-G-407-Dx tumorAnaplastic Oligodendroglioma-35
COG-B-277-PD  Dysembryoplastic Neuroepithelial Tumor--1
CHLA-260-PD tumorGlioblastoma Multiforme--1
CHLA-47-Dx tumorEmbryonal Carcinoma--4
COG-EP-271-Dx tumorEpendymoma, anaplastic--18fibroblasts
COG-EP-280-PD tumorEpendymoma, anaplastic--12fibroblasts

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive