CHILDHOOD CANCER REPOSITORY

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Rhabdomyosarcoma

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePDXPhase of TherapyDiagnosisSample TypeAgep53pO2
        2% O25% O220%O2
Rh18-DxRhabdomyosarcoma, embryonalperineum 2N--✓
Rh30-DxRhabdomyosarcoma, alveolarbone marrow17F--✓
Rh41-PDRhabdomyosarcoma, alveolarlung tumor  --✓
CB-NJR--Rhabdomyosarcomaunknown   - - ✓
CB-NJR--Rhabdomyosarcomaunknown   - - ✓
SMS-CTR--Rhabdomyosarcoma, embryonal    - - ✓
CHLA-33--Rhabdomyosarcomatumor   - - ✓
CHLA-37-DxRhabdomyosarcomatumor   - - ✓
CHLA-50--Rhabdomyosarcomatumor   - - ✓
CHLA-186-PD-BMTRhabdomyosarcomaperitoneal fulid   - - ✓
COG-R-262-PD-BMTRhabdomyosarcomapericardial fluid   - - ✓
COG-R-264-PD-BMTRhabdomyosarcoma    - - ✓
COG-R-267--Rhabdomyosarcomabrain tumor   - - ✓
-COG-R-438xPDRhabdomyosarcomatumor  ---
COG-R-466h-PD-PMRhabdomyosarcoma, embryonaltumor (autopsy)   - ✓ -
-COG-R-668xDxRhabdomyosarcomatumor  ---

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

3 - TP53 gene function
F: Functional
N: Non-Functional

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive