CHILDHOOD CANCER REPOSITORY

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Lymphoid

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell Line NamePDXPhase of DiseaseAge (years)Sample Type ReceivedDiagnosispO2
  2% O25% O220%O2
SMS-SB   tumorPre-B Acute Lymphoblastic Leukemia (ALL)--✓
CHLA-221    Acute Nonlymphocytic Leukemia (ANLL)--✓
CHLA-233    Acute Nonlymphocytic Leukemia (ANLL)--✓
COG-LL-317COG-LL-317xPD bone marrowT-cell Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-319COG-LL-319xDx peripheral bloodPre-B Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-329COG-LL-329xDx bone marrowT-cell Acute Lymphoblastic Leukemia (ALL) - ✓✓
-COG-LL-330x  bone marrowAcute Lymphoblastic Leukemia (ALL)---
COG-LL-332COG-LL-332xPD bone marrowT-cell Acute Lymphoblastic Leukemia (ALL) - ✓✓
-COG-LL-339x  bone marrrowAcute Lymphoblastic Leukemia (ALL) - - -
-COG-LL-343x 16 Pre-B Acute Lymphoblastic Leukemia (ALL) - - -
-COG-LL-350xDx4peripheral bloodPre-B Acute Lymphoblastic Leukemia (ALL) - - -
-COG-LL-351x  bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
COG-LL-355COG-LL-355xDx7bone marrowPre-B Acute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-356h        
-COG-LL-375x 12bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
-COG-LL-377x  bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
-COG-LL-380x   Acute Lymphoblastic Leukemia (ALL) - - -
COG-LL-384h-PD  T-cell Acute Lymphoblastic Leukemia (ALL)   
COG-LL-394COG-LL-394xPD bone marrowAcute Lymphoblastic Leukemia (ALL) - ✓✓
COG-LL-402hCOG-LL-402xDx9bone marrowPre-B Acute Lymphoblastic Leukemia (ALL) - ✓ -
-COG-LL-413x  bone marrowPre-B Acute Lymphoblastic Leukemia (ALL) - - -
COG-LL-434hpendingDx bone marrowT-cell Acute Lymphoblastic Leukemia (ALL)   
-COG-LL-436xDx bone marrowAcute Lymphoblastic Leukemia (ALL) - - -
-COG-LL-456xDx bone marrow  - - -
-COG-LL-489xDx peripheral blood (1st draw)T-cell Leukemia - - -
-COG-LL-492xDx bone marrowT-cell Leukemia - - -
-COG-LL-494xDx peripheral blood (2nd draw)T-cell Leukemia - - -
COG-LL-528hCOG-LL-525xDx bone marrow (right draw)Leukemia - ✓ -
COG-LL-528hCOG-LL-528xDx bone marrowLeukemia - ✓ -
COG-LY-357-Dx bone marrowPre-T Lymphoblastic Lymphoma (LBL)-✓✓
COG-LY-457COG-LY-457xPD-PM10bone marrow (autopsy)Burkitt's Lymphoma✓✓✓
COG-LY-458COG-LY-458xPD-PM10blood (central vein) (autopsy)Burkitt's Lymphoma✓✓✓
COG-LY-459COG-LY-465xPD-PM10blood (left subclavian) (autopsy)Burkitt's Lymphoma✓✓✓
COG-LY-460COG-LY-465xPD-PM10tumor/tumorBurkitt's Lymphoma✓✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive