CHILDHOOD CANCER REPOSITORY

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Ewing's Family of Tumors

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePDXPhase of DiseaseAge (years)EWS/FLI1 Statusp53Sample TypeDiagnosispO2
         2% O25% O220%O2
CB-AGPN-     Primitive Neuroectodermal Tumor (PNET)--✓
CB-DGN-     Primitive Neuroectodermal Tumor (PNET)--✓
CB-JFEN-    tumor (chest wall met)Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-9-Dx14FLI1Ftumor (thoracic mass)Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-10-PD14FLI1Nthoracic lymph nodePrimitive Neuroectodermal Tumor (PNET)--✓
CHLA-25-PD2.6ERGN Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-32-Dx8.5FLI1FtumorPrimitive Neuroectodermal Tumor (PNET)--✓
CHLA-56-Dx   bone marrowPrimitive Neuroectodermal Tumor (PNET)--✓
CHLA-57-     Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-113-PD    PNET / medulloblastoma--✓
CHLA-218-PD   tumorPrimitive Neuroectodermal Tumor (PNET)--✓
CHLA-258-PD-BMT14FLI1Ntumor (lung met)Primitive Neuroectodermal Tumor (PNET)--✓
CHLA-98--   tumorEwing's Sarcoma - - ✓
CHLA-99--   tumorEwing's Sarcoma - - ✓
CHLA-237--   unknownEwing's Sarcoma - - ✓
COG-E-352-PD-PM17ERGNbloodEwing's Sarcoma - ✓✓
-COG-E-670xDx   tumorEwing's Sarcoma---
TC-32 Dx17FLI1N Primitive Neuroectodermal Tumor (PNET)--✓
TC-71 PD22FLI1N Ewing's Sarcoma--✓
TC-106 Dx19 F Ewing's Sarcoma--✓
TC-138   FLI1   --✓
TC-205   FEV   --✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive