CHILDHOOD CANCER REPOSITORY

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Ewing's Family of Tumors

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LineDiseasePhase of DiseaseAge (years)EWS/FLI1 Statusp53Sample TypeDiagnosisDT5
CHLA-9Ewing's Family
of Tumors		Dx14FLI1Ftumor (thoracic mass)Primitive Neuroectodermal
Tumor (PNET)		51
CHLA-10Ewing's Family
of Tumors		PD14FLI1Nthoracic lymph nodePrimitive Neuroectodermal
Tumor (PNET)		32
CHLA-258Ewing's Family
of Tumors		PD-BMT14FLI1Ntumor (lung met)Primitive Neuroectodermal
Tumor (PNET)		89
TC-71Ewing's Family of TumorsPD22FLI1N Ewing's Sarcoma21

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive

DT - Doubling Time (hours)