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Alex's Lemonade Stand Foundation

ALK Mutated

RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53pO2  
LA-N-6PDbone marrowND1091N  F  
SMS-KCNRPDbone marrowAF1174LTERT + F  
SMS-SANDxbone marrowAF1174LTERT + F  
CHLA-27Dxbone marrowAF1174L     
CHLA-52PD-PMbone marrowAF1174LTERT + NF  
CHLA-53PD-PMperipheral bloodAF1174LTERT + NF  
COG-N-295Dxsolid tumorNF1174LTERT +    
COG-N-333Dxbone marrowAF1174LTERT +    
COG-N-415PD-PMbloodAF1174LTERT +   
COG-N-452PD-PMbloodAF1174LTERT + F
COG-N-469hPDleft bone marrowNF1174LTERT +  
COG-N-470PD-PMbloodNF1174LTERT + F 
COG-N-474Dxbone marrowAF1174LTERT +    
CHLA-28PDbone marrowAF1245C     
COG-N-443hPDright bone marrowNF1245CTERT +  
COG-N-534PD-PMbloodNF1245CTERT + NF
COG-N-561PD-PMbloodA F1245ITERT + F
COG-N-557Dxbone marrowAF1245LTERT +  
FelixPD-PMbloodNF1245VTERT + F 
CHLA-90PDbone marrowNF1245VALTE286KNF  
N623FLY-hnbPD-PMbloodNF1275QTERT +    
LA-N-5Dxbone marrowAR1275QTERT +    
NB-1643Dx AR1275QTERT +    
SMS-KCNDxsolid tumorAR1275QTERT + F  
CHLA-15DxtumorNR1275QTERT + F  
CHLA-16Dxpleural fluidNR1275QTERT +    
CHLA-20PDtumor (neck)NR1275QTERT + F  
CHLA-42Dxbone marrowNR1275QTERT + F  
CHLA-61PD-PMperipheral bloodNR1275QTERT + F  
CHLA-150PDbone marrowNR1275Q     
COG-N-294Dxsolid tumorAR1275QTERT + NF  
COG-N-298Dxsolid tumorNR1275QTERT +    
COG-N-367Dxbone marrowAR1275QTERT +   
COG-N-475hPDtumorAR1275Q R342  
COG-N-536hPD-PMbloodAR1275QTERT + NF

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive