CHILDHOOD CANCER REPOSITORY

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ALK Mutated

Cell lines ending in “h” are established and grown in 5% O2. Cells ending in “h2” are established and grown in 2% O2. Cells established and grown in serum-free neurobasal media will end with “nb”.

The defination for the abbreviation are given below the table. Please scroll all the way down.

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RequestCell LinePhase of Therapy Sample TypeMYCN*ALKTMMTp53p53pO2  
         2%5%20%
LA-N-6PDbone marrowND1091N  F  ✓
SMS-KCNRPDbone marrowAF1174LTERT + F  ✓
SMS-SANDxbone marrowAF1174LTERT + F  ✓
CHLA-27Dxbone marrowAF1174L     ✓
CHLA-52PD-PMbone marrowAF1174LTERT + NF  ✓
CHLA-53PD-PMperipheral bloodAF1174LTERT + NF  ✓
COG-N-295Dxsolid tumorNF1174LTERT +    ✓
COG-N-333Dxbone marrowAF1174LTERT +    ✓
COG-N-415PD-PMbloodAF1174LTERT +   ✓✓
COG-N-452PD-PMbloodAF1174LTERT + F✓✓✓
COG-N-469hPDleft bone marrowNF1174LTERT +  ✓✓✓
COG-N-470PD-PMbloodNF1174LTERT + F✓✓ 
COG-N-474Dxbone marrowAF1174LTERT +   ✓ 
COG-N-549PDtumorNF1174LTERT+  ✓✓✓
CHLA-28PDbone marrowAF1245C     ✓
COG-N-443hPDright bone marrowNF1245CTERT +  ✓✓✓
COG-N-534PD-PMbloodNF1245CTERT + NF✓✓✓
COG-N-561PD-PMbloodA F1245ITERT + F✓✓✓
COG-N-557Dxbone marrowAF1245LTERT +  ✓✓✓
FelixPD-PMbloodNF1245VTERT + F ✓✓
CHLA-90PDbone marrowNF1245VALTE286KNF  ✓
N623FLY-hnbPD-PMbloodNF1275QTERT +   ✓ 
LA-N-5Dxbone marrowAR1275QTERT +    ✓
NB-1643Dx AR1275QTERT +    ✓
SMS-KCNDxsolid tumorAR1275QTERT + F  ✓
CHLA-15DxtumorNR1275QTERT + F  ✓
CHLA-16Dxpleural fluidNR1275QTERT +    ✓
CHLA-20PDtumor (neck)NR1275QTERT + F  ✓
CHLA-42Dxbone marrowNR1275QTERT + F  ✓
CHLA-61PD-PMperipheral bloodNR1275QTERT + F  ✓
CHLA-95PDtumorAR1275Q     ✓
CHLA-150PDbone marrowNR1275Q     ✓
CHLA-151DxtumorAR1275Q     ✓
COG-N-294Dxsolid tumorAR1275QTERT + NF  ✓
COG-N-298Dxsolid tumorNR1275QTERT +    ✓
COG-N-367Dxbone marrowAR1275QTERT +   ✓✓
COG-N-475hPDtumorAR1275Q R342  ✓✓
COG-N-536hPD-PMbloodAR1275QTERT + NF✓✓

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive